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Dr. Pradhan’s research focuses on the role of opioid receptors in migraine, and molecular mechanisms of migraine chronicity. |
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Studies the negative affective behaviors associated with the withdrawal phase of addiction and the interaction of endogenous opioid systems with commonly prescribed opioid analgesics.
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Expertise in neural mechanisms underlying the emotional distress associated with stress, chronic pain, and addiction.
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Research is aimed at attaining functional selectivity of opioid agonist action from its own target adverse effects while integrating chemical synthesis with biochemical, genetic, and pharmacological approaches.
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Research in the Che lab is foucused on comprehensively characterizing and dissecting the molecular mechanisms of opioid receptor signaling in order to gain an atomic-level understanding of opioid receptor activation, and to use this information to develop chemical and synthetic biologic tools.
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Research is concentrated on drug design and organic synthesis. He designs and synthesizes novel small organic molecules as modulators of nuclear hormone receptors for the therapeutic treatment of cancer, fatty liver diseases, Alzheimer’s Disease, and Atherosclerosis.
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Researching novel nuclear receptor compounds to supress inflammasomes in myoblasts for the treatment of muscular dystrophy, in particular Duchene Muscular Dystrophy.
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Computational scientist focusing on nuclear receptors structors and identification of novel ligands.
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